Cyber-physical systems (CPS) integrate computational algorithms and physical components, which are used in applications like smart grids, medical monitoring, as well as autonomous automobile, industrial control and robotics systems. The EU-funded MYRTUS project aims at unlocking the new living dimension of CPS, embracing the principles of the TransContinuum Initiative, integrating edge, fog and cloud computing platforms. This integration requires the reinvention of programming languages and tools to orchestrate collaborative distributed and decentralised components. Additionally, components must be augmented with interface contracts covering both functional and non-functional properties. MYRTUS solutions play a crucial role in enabling sustainable computing and trustworthiness in CPS. The project collaborates with relevant initiatives, including IPCEI, Gaia-X and the TransContinuum Initiative to establish synergies and promote strategic industrial partnerships.