Can humans and artificial intelligence (AI) work together in ever-changing, unstructured environments? This is a critical question in a world where AI plays a vital role in decision-making. In this context, the EU-funded HumAIne project will create an operating system for human-AI collaboration. The aim is to empower the development of advanced decision-making applications across various industrial sectors. This will enable AI solution integrators to create collaborative systems that outperform isolated AI systems and human efforts. The project will integrate four essential components: active learning, neuro-symbolic learning, swarm learning and explainable AI. These cutting-edge paradigms place the human operator at the centre, offering complete control and understanding of the operations performed, and ensuring seamless collaboration between humans and AI.